June 2018: Postdoctoral position in the NOREPOS research network is announced

The Norwegian Institute of Public Health has announced a Post Doc position in the RCN funded project: Novel aspects of an old problem. The application deadline is 17 August 2018.

See the announcement.

Read more about the research project here.

20 June 2018: Dissertation: Mortality and risk factors related to osteoporosis and osteoporotic fractures.

M.D. and endocrinologist Trine Elisabeth Finnes, research fellow in NOREPOS, will defend her thesis: “Mortality and risk factors related to osteoporosis and osteoporotic fractures” at the Medical Faculty, University of Oslo. The topic of her trial lecture is: “Hip Fractures: Advantages and disadvantages of epidemiologic observational studies versus randomized studies”.

Hip fractures represent one of the most serious consequences of osteoporosis, leading to loss of independence and a high excess mortality. To effectively prevent fractures, it is important to be able to identify the at-risk population. The aim of this dissertation was to investigate the risk of hip fracture at different levels of the bone formation marker procollagen type 1 aminoterminal propeptide (P1NP) and at different levels of vitamin K1 in the blood. In addition, Finnes and colleagues have investigated whether mortality after hip fractures changed from 1978 to 1996.

Data from large population-based studies in Norway in 1994-2001 were applied to investigate the risk of hip fracture according to serum P1NP levels and vitamin K levels, respectively. To study mortality, hip fracture patients identified in previous studies in Oslo were followed up for at least 10 years with regard to deaths.

There was no clear association between P1NP and hip fracture incidence. Low vitamin K1 concentrations were associated with increased fracture risk, and this relationship was most pronounced among those who also had poor vitamin D status. It cannot be inferred from this study whether vitamin K supplementation may prevent hip fractures. Mortality after hip fractures changed very little from 1978 to 1996 and was about three times higher than in the background population of corresponding age and gender. However, in the oldest (85 years and older), there was some improvement in one-year survival in 1996 compared to 1978. It is important to continue to follow this trend to assess whether follow-up of hip fracture patients is adequate.

The trial lecture and defense both take place 20 June 2018 in Frederik Holst hus, Kirkeveien 166, Oslo.

More information at the University of Oslo (in Norwegian).

May 2018: Dissertation: Vitamin B supplementation, self-reported memory loss and fracture risk

M.D. Maria Garcia Lopez, research fellow in NOREPOS, defended her thesis: “Risk of fracture: The importance of B-vitamins and self-reported memory loss” at the Medical Faculty, University of Oslo on the 25 May 2018. The topic of her trial lecture was: “Gender differences in hip fracture epidemiology and etiology”.

The aim of this thesis was to assess the possible risk of cognitive impairment at early stages (self-perceived memory loss) on hip fracture, and if homocysteine-lowering treatment with B-vitamins had any preventive effect on fracture risk. Elderly who reported self-perceived memory loss had higher risk of hip fractures (men with 41% and women with 90% higher risk) compared to those without memory disorders. Concerning vitamin supplementation, those who received vitamin B6 had 42% higher hip risk compared to those who did not get vitamin B6. Folic acid and vitamin B12 treatment did not affect the risk of hip fractures. The dose of vitamin B6 used was far higher than what is found in the diet and is considered a pharmacological dose. However, these vitamin doses can be found in dietary supplements in different European countries or on the Internet. The vitamin B6 discovery has potential health consequences, mainly related to vitamin consumption and the need to respect the daily dosage recommendations when there is no vitamin deficit. The use of dietary supplements with high doses of vitamins can lead to unexpected adverse side effects.

More information at the University of Oslo (in Norwegian).

January 2018: New NOREPOS research project

The NOREPOS research network has received a grant from the Research Council of Norway (FRIMEDBIO) to carry out a large research project in the period 2018-2021. FRIMEDBIO funds independent research projects within medicine, health sciences and biology. In particular, the FRIMEDBIO scheme aims to promote “scientific quality at the forefront of international research” and “boldness in scientific thinking and innovation”. Our new research project is entitled: Novel aspects of an old problem. The Norwegian Epidemiologic Osteoporosis Studies. The project has three work packages affiliated at the Norwegian Institute of Public Health, the University of Bergen, and the University of Oslo, respectively. Two Post Doc positions and one Researcher position will be announced during spring 2018. More information about the project is available here.

September 2015: Anniversary paper about NOREPOS is published

On the occasion of the 10th Annual NOREPOS Workshop this year, a paper describing the history of epidemiologic osteoporosis research in Norway is published in the Norwegian Journal of Epidemiology. The topic of the current issue is the History of Epidemiology in Norway. The paper written by Anne Johanne Søgaard and Grethe S Tell is entitled: An example of a successful national research network in epidemiology – The Norwegian Epidemiologic Osteoporosis Studies (NOREPOS).

April 2015: Date and venue set for the 10th Annual NOREPOS Workshop

The 10th Annual NOREPOS Workshop will take place in Scandic Hotel Nidelven, Trondheim, 27 – 28 October 2015. The program will be announced here.

April 2015: Seminar about geodata and fracture at the Norwegian Institute of Public Health

The Norwegian Institute of Public Health carried out an open seminar with the topic “Kan geodata knekke bruddgåten?”

View programme (in Norwegian).

October 2014: NOREPOS cohort profile published

The background paper describing the NOREPOS network and data material is now available online. Reference:

Søgaard AJ, Meyer HE, Emaus N, Grimnes G, Gjesdal CG, Forsmo S, Schei B, Tell GS. Cohort profile: Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). Scand J Public Health 2014 Oct 2 [Epub ahead of print]

View full publication online at SAGE journals

September 2014: Dissertation: Vitamin K, inflammation, and osteoporosis

On 23 September, rheumatologist Ellen M Apalset defended her thesis “Vitamin K and inflammation in relation to bone mineral density and hip fractures” at the University of Bergen.

The study is based on data from the Hordaland Health Study (HUSK), which was conducted from 1997 to 1999 with 10 years follow-up of hip fractures recorded by the hospitals in the county.

Dietary vitamin K1 and K2 and blood markers of interferon-gamma mediated inflammation were examined.

Low dietary vitamin K1 diet was associated with low bone density among women but not in men. Older people (71-74 years) with a low intake of vitamin K1 had an increased risk of hip fracture. Vitamin K2 in the diet showed no association with bone density or risk of hip fracture.

Among the oldest there was an association between higher blood levels of certain inflammation markers and low bone density. In middle-aged people (47-49 years) there was no such correlation. The oldest also had a greater risk of hip fracture at higher levels of inflammation markers.

High intake of vitamin K1 is related to a healthy diet and lifestyle, and the study cannot conclude as to whether vitamin K1 protects against osteoporosis and fractures. A link between inflammation and osteoporosis has been shown also earlier, but this is the first time this part of the immune system has been studied in the context of bone density and fracture risk in a larger population study.

Read more (in Norwegian)

June 2014: New NOREPOS Dissertation

Cecilie Dahl defended her thesis 2 June 2014, entitled: “Quality of municipal drinking water and the risk of osteoporotic fractures in Norway”.

The dissertation consists of three sub-studies where Dahl studied differences in fracture risk according to drinking water quality in nationwide data. Results from the first sub-study showed that the drinking water that was slightly acidic often was less hygienic, and it was also associated with a higher incidence of forearm fractures. In the second sub-study, Dahl found that a higher magnesium content in drinking water could be protective against hip fracture, whereas a higher level of calcium was not associated with hip fractures.

In the third sub-study, the concentrations of metals such as lead, cadmium and aluminum in drinking water were examined. A higher level of the heavy metal cadmium was associated with increased risk of hip fractures in men. More lead in drinking water also appeared to be associated with increased risk of hip fractures in both genders, but a statistical association was only seen in the oldest (66-85 years).

The results show that the quality of drinking water, in particular low magnesium content, is correlated with high incidence of osteoporotic fractures in Norway. Since this is the first study of its kind in the world, we need more studies before concluding. The next step will be to examine how substances in drinking water may affect bone health.

March 2014: Date and venue set for NOREPOS workshop 2014

The 9th annual NOREPOS workshop will take place 18-19 June in Solstrand Hotel & Bad outside Bergen. The final program will be announced in May. More information

November 2013: Dissertation: Svanhild Waterloo

Cand. san. Svanhild Haugnes Waterloo will defend her thesis for the degree Ph.D. in the University of Tromsø Friday 8th November 2013. The topic is vertebral fractures in the sixth Tromsø study.

May 2013: Date and venue set for next NOREPOS workshop

This year’s NOREPOS workshop will take place 26-27 August in beautiful Malangen Brygger in Troms, approximately one hour drive from Langnes Airport in Tromsø. The program will be announced here.

NIPH website: “Risikoen for hoftebrudd faller, men fortsatt rundt 9000 brudd per år”

Read here

February 2012: Date and venue set for this year’s NOREPOS workshop

This year’s NOREPOS workshop will take place 20-21 September in Hurdalsjøen in Akershus, 30 minutes drive north of Gardermoen Airport. Please mark the dates in your calendar now! More information will be available soon.

February 2012: Norwegian data in FRAX®

We have contributed our nationwide data on hip fracture incidence to the World Health Organization’s Fracture Risk Assessment Tool. The calculation tool to estimate individual ten-year risk of fracture based on common risk factors is now adapted to Norwegian conditions. It can be found here.

Acknowledgements: Tone K. Omsland and Haakon E. Meyer on behalf of the NOREPOS collaboration

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